Proton-activated rubidium transport catalyzed by the sodium pump.
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چکیده
منابع مشابه
Proton diet for the sodium pump.
In the absence of Na(+) and K(+) ions the Na,K-ATPase shows a pH-dependent ATP hydrolysis that can be inhibited by ouabain. At pH 7.2 this activity is 5% of the maximal under physiological conditions. It could be inferred that this activity is associated with H(+) transport in both directions across the membrane and facilitates an H-only mode of the sodium pump under such unphysiological condit...
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The effects of 0.3-10 nM extracellular protons (pH 9.5-8.0) on ouabain-sensitive rubidium influx were determined in 4,4'-diisocyanostilbene-2, 2'-disulfonate (DIDS)-treated human and rat erythrocytes. This treatment clamps the intracellular H. We found that rubidium binds much better to the protonated pump than the unprotonated pump; 13-fold better in rat and 34-fold better in human erythrocyte...
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C omplex I (NADH quinone oxidoreductase) is the only enzyme of the membrane-bound respiratory chain to remain a ‘‘black box.’’ Atomic resolution structural models are available for three of the four energy-transducing respiratory complexes: the cytochrome bc1 complex, cytochrome oxidase, and the F1 domain of ATP synthase. Detailed mechanisms that integrate these structural models with the resul...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1985
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(20)71173-7